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Adipocytes undergo adipogenesis, a differentiation process signaled by stimuli and receptor activations such as peroxisome proliferator-activated receptor (PPAR) and insulin-like growth factor 1 (IGF-1)

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It may be used as monotherapy when metformin is considered inappropriate due to intolerance or contraindications, or in combination with other glucose-lowering medicines when existing therapy does not provide adequate glycaemic control